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The important one is sales." The juggernaut of the Marlboro Man also seemed to supersede the health concerns about cigarettes, which were being raised as early as the 1950s

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For example, in IL-1-deficient mice, neither local tumors nor lung metastases developed after localized or intravenous inoculation with melanoma cell lines, which suggests that IL-1-induced inflammation participates in the invasiveness of already existing tumor cells [65]